反应详情

Around-bottom flask, containing a solution of 5-nitro-2-(pyrrolidin-1-yl)pyridine (compound 40.1, 1.93 g, 10.00 mmol, 1.00 equiv) in ethanol (30 mL) was purged with nitrogen. Palladium on carbon (0.4 g, 10%, 60% water) was added. After further purging the system with nitrogen, the atmosphere was changed to hydrogen and the resulting mixture was stirred overnight at room temperature. After purging the system with nitrogen, the solids were filtered off and the filtrate was concentrated under reduced pressure and dried to yield 1.6 g (98%) of the title compound as a brown solid.

1. customwas purged with nitrogen
2. additionPalladium on carbon (0.4 g, 10%, 60% water) was added
3. customAfter further purging the system with nitrogen
4. customAfter purging the system with nitrogen
5. filtrationthe solids were filtered off
6. concentrationthe filtrate was concentrated under reduced pressure
7. customdried