2-Furancarboxylic acid, tetrahydro-, hydrazide, (2S)- → HCID 178424708, compound

HRID 541256Notes

Reaction equation

HRID 541256 reaction equation
[CH3:1][C:2]1[CH:23]=[C:22]([CH3:24])[C:21]([C:25]2[NH:29][C:28]([CH2:30][CH:31]3[CH2:35][CH2:34][O:33]C3)=[N:27][N:26]=2)=[CH:20][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5].O1CCC[C@H]1C(NN)=O.O1CCC(CC(NN)=O)C1>>[CH3:1][C:2]1[CH:23]=[C:22]([CH3:24])[C:21]([C:25]2[NH:29][C:28]([C@@H:30]3[CH2:31][CH2:35][CH2:34][O:33]3)=[N:27][N:26]=2)=[CH:20][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5]

Participants

4

Reactant 3

HCID 405663202-Furancarboxylic acid, tetrahydro-, hydrazide, (2S)-2×HCID 682888162-(Tetrahydrofuran-3-yl)acetohydrazideHCID 1784247044-(1-(2,4-dimethyl-5-(5-((tetrahydrofuran-3-yl)methyl)-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile2×

Product 1

HCID 178424708HCID 178424708, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of 4-(1-(2,4-dimethyl-5-(5-((tetrahydrofuran-3-yl)methyl)-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile (compound 130), using (S)-tetrahydrofuran-2-carbohydrazide (compound 136.1) instead of 2-(tetrahydrofuran-3-yl)acetohydrazide (compound 130.4). m/z (ES+) 456 (M+H)+.

Sources & evidence

ORD record
ord-fc40c4cd14784395a74a24497c6d86fb
Source dataset
uspto-grants-2014_10
Patent number
US08871790B2

Reaction notes

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