HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 541288Generated: November 2, 2026
Hydrazine hydrate (1:1) → (2R)-oxolane-2-carbohydrazide
https://huagongshe.com/reaction/541288
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Tetrahydro-2-furoic acid, (+)- | HCID 2734707 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2R)-oxolane-2-carbohydrazide | HCID 40566306 | 59.6% |
Reaction Steps
To a round-bottom flask was added a solution of (R)-tetrahydrofuran-2-carboxylic acid (3.00 g, 25.8 mmol, 1.00 equiv) in dichloromethane (60 mL). EDC.HCl (7.37 g, 38.5 mmol, 1.50 equiv), HOBt (5.24 g, 38.8 mmol, 1.50 equiv), and hydrazine hydrate (2.60 g, 51.9 mmol, 2.00 equiv) were added to the reaction. The resulting solution was stirred overnight at 25° C. The solids were removed with filtration. The filtrate was concentrated in vacuo to yield 2.00 g (59%) of (R)-tetrahydrofuran-2-carbohydrazide as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08871790B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-3bff4fe272fe451c990ef9e6a97ec23a |
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| Source note | uspto-grants-2014_10 |
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