反应详情

温度

80 °C

Methyl 5-((ethylthio)(imino)methyl)-4-isopropyl-2-methylbenzoate (compound 198.4, 33 mg, 0.12 mmol, 1.0 equiv), 3-methoxypropanehydrazide (compound 143.1, 21 mg, 0.18 mmol, 1.5 equiv) and acetic acid (1.2 mL) were added to a 4-mL vial and heated at 80° C. with a loose cap for 4 hours. The solvent was removed in vacuo and the residue was dissolved in DCM (10 mL) and washed with saturated NaHCO3 (5 mL) then brine (5 mL), dried (Na2SO4), filtered and evaporated to a colorless oil (theoretical yield). m/z (ES+) 318 (M+H)+.

1. customa loose cap for 4 hours
2. customThe solvent was removed in vacuo
3. dissolutionthe residue was dissolved in DCM (10 mL)
4. washwashed with saturated NaHCO3 (5 mL)
5. dry with materialbrine (5 mL), dried (Na2SO4)
6. filtrationfiltered
7. customevaporated to a colorless oil (theoretical yield)