3-Methoxypropanehydrazide → HCID 178436213, compound

HRID 541335Notes

Reaction equation

HRID 541335 reaction equation
[CH2:1]([C:3]1[CH:24]=[C:23]([CH2:25][CH3:26])[C:22]([C:27]2[NH:31][C:30]([CH2:32][CH2:33][O:34][CH3:35])=[N:29][N:28]=2)=[CH:21][C:4]=1[C:5]([N:7]1[CH2:12][CH2:11][CH:10]([C:13]2[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=2)[CH2:9][CH2:8]1)=[O:6])[CH3:2].O1CCC(C(NN)=O)[CH2:37]1.COCCC(NN)=O>>[CH2:1]([C:3]1[CH:24]=[C:23]([CH2:25][CH3:26])[C:22]([C:27]2[NH:31][C:30]([CH:32]3[CH2:37][CH2:35][O:34][CH2:33]3)=[N:29][N:28]=2)=[CH:21][C:4]=1[C:5]([N:7]1[CH2:12][CH2:11][CH:10]([C:13]2[CH:14]=[CH:15][C:16]([C:17]#[N:18])=[CH:19][CH:20]=2)[CH2:9][CH2:8]1)=[O:6])[CH3:2]

Participants

4

Reactant 3

HCID 27597273-MethoxypropanehydrazideHCID 46942244Oxolane-3-carbohydrazide2×HCID 178436214HCID 178436214, compound2×

Product 1

HCID 178436213HCID 178436213, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of 4-(1-(2,4-diethyl-5-(5-(2-methoxyethyl)-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile (compound 209) but using tetrahydrofuran-3-carbohydrazide (compound 38.2) instead of 3-methoxypropanehydrazide (compound 143.1). m/z (ES+) 484.05 (M+H)+.

Sources & evidence

ORD record
ord-7edf0beebe4249e6974767056559913a
Source dataset
uspto-grants-2014_10
Patent number
US08871790B2

Reaction notes

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