反应详情

To a solution of methyl 1-methyl-5-nitro-1H-pyrazole-3-carboxylate (351.2, 0.48 g, 2.60 mmol) in MeOH (15 ml) under nitrogen was added palladium on carbon (10%, 0.25 g). The flask was further degassed with nitrogen and filled with H2 through a balloon. The mixture was stirred at room temperature for 1.5 hours. After purging the system with nitrogen, the reaction mixture was filtered through a Celite cake and concentrated to give 363 mg (90%) of a white solid. m/z (ES+) 156 (M+H)+.

1. customThe flask was further degassed with nitrogen
2. additionfilled with H2 through a balloon
3. customAfter purging the system with nitrogen
4. filtrationthe reaction mixture was filtered through a Celite cake
5. concentrationconcentrated