反应详情

温度

20 °C

A flask containing a solution of methyl 4-cyclobutyl-3-nitrobenzoate (compound 443.1, 2.50 g, 10.6 mmol, 1.00 equiv) in methanol (30 mL) was purged with nitrogen. Palladium on carbon (10%, 60% water, 1.2 g) was added and the flask was carefully purged further with nitrogen. The atmosphere was then changed to hydrogen and the mixture was stirred overnight at 20° C. After purging the system with nitrogen, the solids were then removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified using silica gel column chromatography with ethyl acetate/petroleum ether (1:5) as eluent to yield 1.60 g (73%) of the title compound as a white solid.

1. customwas purged with nitrogen
2. additionPalladium on carbon (10%, 60% water, 1.2 g) was added
3. customthe flask was carefully purged further with nitrogen
4. customAfter purging the system with nitrogen
5. customthe solids were then removed by filtration
6. concentrationthe filtrate was concentrated under reduced pressure
7. customThe residue was purified