HCID 68288739, compound → HCID 68289036, compound

Participants

Reaction Steps

A solution of methyl 4-cyclobutyl-2-methyl-5-(2H-1,2,3-triazol-4-yl)benzoate (compound 446.3, 92 mg, 0.34 M) in 2N NaOH (1.5 ml) and methanol (MeOH) (4 ml) was heated at 50° C. for 16 hours. After cooling to room temperature, the methanol was removed under reduced pressure. The residue was neutralized with 2N HCl to pH 3-4 and extracted with EtOAc. The organic phase was then washed with brine, dried (MgSO4), and concentrated to yield 83 mg of a white solid that was used without further purification. m/z (ES−) 256 (M−H)+.

Provenance & Evidence