Methyl 2-bromo-4-fluorobenzoate → Methyl 2-ethyl-4-fluorobenzoate

HRID 541484Notes

Reaction equation

HRID 541484 reaction equation
[CH2:1]([C:3]1[CH:12]=[C:11](C)[CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6])[CH3:2].BrC1C=C([F:25])C=CC=1C(OC)=O>>[CH2:1]([C:3]1[CH:12]=[C:11]([F:25])[CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6])[CH3:2]

Participants

3

Reactant 2

HCID 7210837Methyl 2-bromo-4-fluorobenzoate2×HCID 68288774Methyl 2-ethyl-4-methylbenzoate

Product 1

HCID 68288928Methyl 2-ethyl-4-fluorobenzoateYield 93%

Procedure

The title compound (colorless oil, 14.5 g, 93%) was prepared using a procedure similar to that used for the preparation of compound 48.1 and using of methyl 2-bromo-4-fluorobenzoate (compound 470.1, 20.0 g) in place of methyl 2-bromo-4-methylbenzoate.

Sources & evidence

ORD record
ord-54f0e94a95bc4cb2a039b0cffdfbd502
Source dataset
uspto-grants-2014_10
Patent number
US08871790B2

Reaction notes

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