Dichloromethane → HCID 69015898, compound

Participants

Reaction Steps

6-Chloro-12-(2-oxo-2-piperazin-1-ylethoxy)-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene trifluoroacetate (10.0 mg, 0.017 mmol) was stirred in N,N-dimethylformamide (0.5 mL) and methylene chloride (0.5 mL) with triethylamine (12.0 μL, 0.086 mmol), and 4-isocyanatobenzonitrile (2.7 mg, 0.019 mmol) was added. Purification by preparative LCMS (pH 2) gave the desired compound (8%). LCMS for C32H30ClN8O3 (M+H)+: m/z=609.2.

Provenance & Evidence