HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Benzodioxole-5-carbonyl chloride → 1-(1,3-Benzodioxol-5-ylcarbonyl)-N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide Trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Benzodioxole-5-carbonyl chloride | HCID 2734749 | — |
| Reactant | N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide bis(trifluoroacetate) | HCID 86636132 | — |
| Product | 1-(1,3-Benzodioxol-5-ylcarbonyl)-N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide Trifluoroacetate | HCID 69018955 | 16% |
Reaction Steps
The desired compound was prepared according to the procedure of Example A20, using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide bis(trifluoroacetate) and 1,3-benzodioxole-5-carbonyl chloride as starting materials in 16% yield. LCMS for C32H30ClN6O4 (M+H)+: m/z=597.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871753B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-a62a99154d9b4a0a9c0ed8e4a483e736 |
| Source note | uspto-grants-2014_10 |