Phenylacetyl chloride → N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-1-(phenylacetyl)piperidine-4-carboxamide Trifluoroacetate

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Reaction Steps

The desired compound was prepared according to the procedure of Example A20, using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide bis(trifluoroacetate) and benzeneacetyl chloride as starting materials in 70% yield. 1H NMR (300 MHz, DMSO-d6): δ 9.61 (s, 1H), 9.44 (s, 1H), 9.32 (s, 1H), 8.18 (s, 1H), 7.97 (s, 1H), 7.72 (s, 1H), 7.20 (m, 7H), 7.03 (m, 2H), 6.89 (d, 1H), 6.79 (d, 1H), 4.42 (d, 1H), 4.01 (d, 1H), 3.73 (s, 2H), 3.02 (m, 1H), 2.81 (m, 4H), 2.63 (m, 2H), 1.80 (m, 2H), 1.41 (m, 2H). LCMS for C32H32ClN6O2(M+H)+: m/z=567.2.

Provenance & Evidence