3-Methoxyphenyl isocyanate → HCID 69015662, compound

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A9, step H using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide bis(trifluoroacetate) and 1-isocyanato-3-methoxybenzene as starting materials in 66% yield. 1H NMR (300 MHz, DMSO-d6): δ 9.49 (s, 1H), 9.40 (s, 1H), 9.33 (s, 1H), 8.49 (s, 1H), 8.17 (s, 1H), 7.98 (s, 1H), 7.72 (s, 1H), 7.10 (m, 5H), 6.87 (d, 1H), 6.79 (d, 1H), 6.48 (d, 1H), 4.20 (d, 2H), 3.68 (s, 3H), 2.87 (m, 6H), 2.66 (m, 1H), 1.89 (m, 2H), 1.61 (m, 2H). LCMS for C32H33ClN7O3 (M+H)+: m/z=598.2.

Provenance & Evidence