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HRID 541592作成日：2026年10月25日

1-Isocyanato-2-(methylsulfanyl)benzene → N(4)-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-N(1)-[2-(methylthio)phenyl]piperidine-1,4-dicarboxamide Trifluoroacetate

https://huagongshe.com/reaction/541592

反応式

関与物質

役割名称HCID仕込み量
反応物1-Isocyanato-2-(methylsulfanyl)benzeneHCID 2736989—
反応物N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide bis(trifluoroacetate)HCID 86636132—
生成物N(4)-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-N(1)-[2-(methylthio)phenyl]piperidine-1,4-dicarboxamide TrifluoroacetateHCID 6901898649%

反応手順

The desired compound was prepared according to the procedure of Example A9, step H using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide bis(trifluoroacetate) and 1-isocyanato-2-(methylthio)benzene as starting materials in 49% yield. LCMS for C32H32ClN7O2S (M+H)+: m/z=614.2.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08871753B2
出典データセットuspto-grants-2014_10
ORD IDord-d404665479e04a2ea177d7cd3702bdfb
出典メモuspto-grants-2014_10