反应详情

Methyl (3R)-6-methoxycarbonyl-5oxo-1-thia-4-azacyclotridecane-3-carboxylate (2.39 g, 7.21 mmol) is suspended in methanol (75 ml) and 1N sodium hydroxide (22.0 ml, 22.0 mmol) is added. The mixture is stirred for 4 hours at room temperature. The solvent is evaporated and the residue is dissolved in water (150 ml). The aqueous solution is adjusted to pH 1 by addition of 1N hydrochloric acid and extracted with ethyl acetate (3×100 ml). The combined extracts are washed with brine (1×100 ml), dried (MgSO4) and the solvent is evaporated to give (3R)-6-carboxy-5-oxo-1-thia-4-azacyclotridecane-3-carboxylic acid, m.p. 167°-170° C.

1. customThe solvent is evaporated
2. dissolutionthe residue is dissolved in water (150 ml)
3. additionThe aqueous solution is adjusted to pH 1 by addition of 1N hydrochloric acid
4. extractionextracted with ethyl acetate (3×100 ml)
5. washThe combined extracts are washed with brine (1×100 ml)
6. dry with materialdried (MgSO4)
7. customthe solvent is evaporated