Phenyl isocyanate → HCID 69015428, compound

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A9, step H using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-3-carboxamide bis(trifluoroacetate) and phenyl isocyanate as starting materials in 42% yield. 1H NMR (300 MHz, DMSO-d6): δ 9.43 (s, 1H), 9.40 (s, 1H), 9.38 (s, 1H), 8.59 (s, 1H), 8.14 (s, 1H), 8.00 (s, 1H), 7.72 (s, 1H), 7.44 (d, 2H), 7.21 (m, 3H), 7.04 (m, 2H), 6.90 (m, 2H), 4.22 (d, 1H), 4.10 (d, 1H), 2.90 (m, 6H), 2.63 (m, 1H), 2.03 (m, 1H), 1.72 (m, 2H), 1.47 (m, 1H). LCMS for C31H31ClN7O2 (M+H)+: m/z=568.2.

Provenance & Evidence