Phenyl isocyanate → HCID 69013371, compound

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A9, step H using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) and phenyl isocyanate as starting materials in 53% yield. 1H NMR (300 MHz, DMSO-d6): δ 9.49 (s, 1H), 9.38 (s, 1H), 9.35 (s, 1H), 8.47 (s, 1H), 8.12 (s, 1H), 7.99 (s, 1H), 7.72 (s, 1H), 7.43 (d, 2H), 7.20 (m, 3H), 7.04 (m, 2H), 6.90 (m, 2H), 6.78 (d, 1H), 4.15 (d, 2H), 2.82 (m, 6H), 2.30 (d, 2H), 2.00 (m, 1H), 1.72 (m, 2H), 1.20 (m, 2H). LCMS for C32H33ClN7O2 (M+H)+: m/z=582.2.

Provenance & Evidence