Phenyl isocyanate → HCID 69015062, compound

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A9, step H using (2S)—N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]pyrrolidine-2-carboxamide bis(trifluoroacetate) and phenyl isocyanate as starting materials in 44% yield. 1H NMR (300 MHz, DMSO-d6): δ 9.43 (s, 2H), 9.36 (s, 1H), 8.30 (s, 1H), 8.11 (s, 1H), 7.98 (s, 1H), 7.72 (s, 1H), 7.58 (d, 2H), 7.25 (m, 3H), 7.04 (m, 2H), 6.95 (m, 1H), 6.85 (d, 1H), 4.53 (m, 1H), 3.68 (m, 1H), 3.50 (m, 1H), 2.85 (m, 4H), 2.20 (m, 1H), 2.01 (m, 3H). LCMS for C30H29ClN7O2 (M+H)+: m/z=554.2.

Provenance & Evidence