[1-(tert-Butoxycarbonyl)piperidin-4-yl]acetic acid → HCID 86636147, compound

HRID 541619Notes

Reaction equation

HRID 541619 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]([F:14])([F:13])[C:10]([OH:12])=[O:11].FC(F)(F)C(O)=O.[Cl:22][C:23]1[CH:24]=[N:25][C:26]2[NH:27][C:28]3[CH:29]=[N:30][CH:31]=[C:32]([CH:45]=3)[CH2:33][CH2:34][C:35]3[CH:43]=[C:39]([NH:40][C:41]=1[N:42]=2)[CH:38]=[CH:37][C:36]=3[NH2:44].[C:46]([O:50][C:51]([N:53]1[CH2:58][CH2:57][CH:56]([CH2:59][C:60](O)=[O:61])[CH2:55][CH2:54]1)=[O:52])([CH3:49])([CH3:48])[CH3:47]>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]([F:14])([F:13])[C:10]([OH:12])=[O:11].[Cl:22][C:23]1[CH:24]=[N:25][C:26]2[NH:27][C:28]3[CH:29]=[N:30][CH:31]=[C:32]([CH:45]=3)[CH2:33][CH2:34][C:35]3[CH:43]=[C:39]([NH:40][C:41]=1[N:42]=2)[CH:38]=[CH:37][C:36]=3[NH:44][C:60](=[O:61])[CH2:59][CH:56]1[CH2:57][CH2:58][N:53]([C:51]([O:50][C:46]([CH3:48])([CH3:47])[CH3:49])=[O:52])[CH2:54][CH2:55]1

Participants

3

Reactant 2

HCID 1512539[1-(tert-Butoxycarbonyl)piperidin-4-yl]acetic acidHCID 86636148HCID 86636148, compound

Product 1

HCID 86636147HCID 86636147, compoundYield 59%

Procedure

The desired compound was prepared according to the procedure of Example A27 using 6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-amine tris(trifluoroacetate) and [1-(tert-butoxycarbonyl)piperidin-4-yl]acetic acid as the starting materials in 59% yield. LCMS for C29H35ClN7O3 (M+H)+: m/z=564.2.

Sources & evidence

ORD record
ord-af72202aa68c4717a16e361a5d1c5268
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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