Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfamide | HCID 82267 | — |
| Reactant | N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide bis(trifluoroacetate) | HCID 86636132 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 69016319 | HCID 69016319 | 7% |
Reaction Steps
To a solution of N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide bis(trifluoroacetate) (10.0 mg, 0.018 mmol) in 1,4-dioxane (1.0 mL) was added sulfamide (17.1 mg, 0.18 mmol) and the mixture was heated to 130° C. in a microwave for 10 minutes. Purification by preparative LCMS (pH 2) gave the desired compound (0.8 mg, 7% yield). LCMS for C24H27ClN7O3S (M+H)+: m/z=528.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08871753B2 |
|---|
| Source dataset | uspto-grants-2014_10 |
|---|
| ORD ID | ord-73f44eab3069421fac1dc5115c367326 |
|---|
| Source note | uspto-grants-2014_10 |
|---|
