Acetyl chloride → 2-(1-Acetylpiperidin-4-yl)-N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]acetamide bis(trifluoroacetate)

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Reaction Steps

The desired compound was prepared according to the procedure of Example A20, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and acetyl chloride as starting materials in 43% yield. 1H NMR (300 MHz, DMSO-d6): δ 10.02 (s, 2H), 9.40 (s, 1H), 9.01 (s, 1H), 8.31 (s, 2H), 8.20 (s, 1H), 7.65 (s, 1H), 7.31 (d, 1H), 7.08 (d, 1H), 4.38 (d, 1H), 3.81 (d, 1H), 3.00 (m, 6H), 2.52 (m, 1H), 2.32 (m, 2H), 2.00 (s, 3H), 1.75 (m, 2H), 1.20 (m, 2H). LCMS for C26H29ClN7O2 (M+H)+: m/z=506.2.

Provenance & Evidence