Dimethylcarbamoyl Chloride → HCID 69019016, compound

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A9, step H using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) and N,N-dimethylcarbamoyl chloride as starting materials in 48% yield. 1H NMR (300 MHz, DMSO-d6): δ 9.57 (s, 1H), 9.43 (s, 1H), 9.32 (s, 1H), 8.17 (s, 1H), 7.97 (s, 1H), 7.72 (s, 1H), 7.21 (d, 1H), 7.10 (m, 1H), 7.01 (d, 1H), 6.88 (d, 1H), 6.80 (d, 1H), 3.57 (d, 2H), 2.91 (m, 2H), 2.83 (m, 2H), 2.71 (m, 8H), 2.32 (d, 2H), 1.93 (m, 1H), 1.70 (m, 2H), 1.20 (m, 2H). LCMS for C28H33ClN7O2 (M+H)+: m/z=534.2.

Provenance & Evidence