tert-Butyl isocyanate → HCID 69017871, compound

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A9, step H using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) and 2-isocyanato-2-methyl-propane as starting materials in 48% yield. 1H NMR (300 MHz, DMSO-d6): δ 9.43 (s, 1H), 9.32 (m, 2H), 8.13 (s, 1H), 8.00 (s, 1H), 7.72 (s, 1H), 7.22 (d, 1H), 7.09 (m, 1H), 7.01 (d, 1H), 6.89 (d, 1H), 6.75 (d, 1H), 5.71 (s, 1H), 3.91 (d, 2H), 2.90 (m, 2H), 2.82 (m, 2H), 2.61 (m, 2H), 2.25 (d, 2H), 1.90 (m, 1H), 1.62 (m, 2H), 1.23 (s, 9H), 1.10 (m, 2H). LCMS for C30H37ClN7O2 (M+H)+: m/z=562.3.

Provenance & Evidence