5-Methoxy-1,2-oxazole-3-carbonyl chloride → HCID 69015214, compound

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A20, using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) and 5-methoxyisoxazole-3-carbonyl chloride as starting materials in 31% yield. 1H NMR (300 MHz, DMSO-d6): δ 9.45 (s, 1H), 9.36 (s, 2H), 8.12 (s, 1H), 7.98 (s, 1H), 7.73 (s, 1H), 7.21 (d, 1H), 7.04 (m, 2H), 6.87 (d, 1H), 6.78 (d, 1H), 6.41 (s, 1H), 4.42 (m, 1H), 3.88 (m, 1H), 3.13 (m, 2H), 2.83 (m, 4H), 2.45 (s, 3H), 2.30 (m, 2H), 2.10 (m, 1H), 1.80 (m, 2H), 1.20 (m, 2H). LCMS for C30H31ClN7O3S (M+H)+: m/z=572.2.

Provenance & Evidence