Pyrazinecarbonyl chloride → HCID 86636152, compound

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A20, using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) and pyrazine-2-carbonyl chloride as starting materials in 36% yield. 1H NMR (300 MHz, DMSO-d6): δ 9.42 (s, 1H), 9.35 (s, 1H), 9.30 (s, 1H), 8.80 (s, 1H), 8.72 (s, 1H), 8.68 (s, 1H), 8.11 (s, 1H), 7.99 (s, 1H), 7.73 (s, 1H), 7.21 (d, 1H), 7.04 (m, 2H), 6.87 (d, 1H), 6.78 (d, 1H), 4.49 (m, 2H), 3.65 (m, 1H), 3.12 (m, 1H), 2.81 (m, 4H), 2.31 (m, 2H), 2.10 (m, 1H), 1.83 (m, 1H), 1.68 (m, 1H), 1.22 (m, 2H). LCMS for C30H30ClN8O2 (M+H)+: m/z=569.2.

Provenance & Evidence