Isobutyryl chloride → HCID 69015343, compound

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A20, using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) and isobutyryl chloride as starting materials in 41% yield. 1H NMR (300 MHz, DMSO-d6): δ 9.45 (s, 1H), 9.38 (s, 1H), 9.31 (s, 1H), 8.12 (s, 1H), 7.98 (s, 1H), 7.73 (s, 1H), 7.21 (d, 1H), 7.04 (m, 2H), 6.87 (d, 1H), 6.78 (d, 1H), 4.40 (m, 2H), 3.95 (m, 2H), 3.03 (m, 1H), 2.83 (m, 4H), 2.27 (m, 2H), 2.01 (m, 1H), 1.76 (m, 2H), 1.10 (m, 2H), 1.00 (m, 6H). LCMS for C29H34ClN6O2 (M+H)+: m/z=533.2.

Provenance & Evidence