Methanesulfonyl chloride → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[1-(methylsulfonyl)pyrrolidin-3-yl]acetamide bis(trifluoroacetate)

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A42, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-pyrrolidin-3-ylacetamide tris(trifluoroacetate) and methanesulfonyl chloride as starting materials in 48% yield. 1H NMR (300 MHz, DMSO-d6): δ 10.10 (s, 1H), 9.48 (s, 1H), 9.41 (s, 1H), 9.08 (s, 1H), 8.33 (s, 2H), 8.21 (s, 1H), 7.69 (s, 1H), 7.32 (d, 1H), 7.09 (d, 1H), 3.95 (s, 2H), 3.44 (m, 1H), 3.37 (m, 1H), 3.25 (m, 1H), 3.00 (m, 4H), 2.90 (s, 3H), 2.62 (m, 1H), 2.05 (m, 1H), 1.62 (m, 2H). LCMS for C24H27ClN7O3S (M+H)+: m/z=528.2.

Provenance & Evidence