Methyl Isocyanate → 3-(2-{[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]amino}-2-oxoethyl)-N-methylpyrrolidine-1-carboxamide bis(trifluoroacetate)

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Reaction Steps

The desired compound was prepared according to the procedure of Example A9, step H using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-pyrrolidin-3-ylacetamide tris(trifluoroacetate) and methyl isocyanate as starting materials in 59% yield. 1H NMR (300 MHz, DMSO-d6): δ 10.04 (s, 1H), 9.40 (m, 2H), 9.05 (s, 1H), 8.32 (m, 2H), 8.21 (s, 1H), 7.68 (m, 1H), 7.30 (m, 1H), 7.07 (m, 1H), 6.03 (m, 1H), 3.40 (m, 3H), 3.20 (m, 2H), 2.99 (m, 4H), 2.55 (s, 3H), 2.00 (m, 2H), 1.60 (m, 2H). LCMS for C25H28ClN8O2 (M+H)+: m/z=507.2.

Provenance & Evidence