Acetyl chloride → 2-(1-Acetylpyrrolidin-3-yl)-N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]acetamide bis(trifluoroacetate)

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Reaction Steps

The desired compound was prepared according to the procedure of Example A20, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-pyrrolidin-3-ylacetamide tris(trifluoroacetate) and acetyl chloride as starting materials in 39% yield. 1H NMR (300 MHz, DMSO-d6): δ 10.08 (s, 1H), 9.40 (m, 2H), 9.07 (s, 1H), 8.32 (m, 2H), 8.21 (s, 1H), 7.67 (m, 1H), 7.30 (m, 1H), 7.07 (m, 1H), 3.50 (m, 4H), 3.17 (m, 1H), 2.99 (m, 4H), 2.08 (m, 2H), 1.91 (s, 3H), 1.60 (m, 2H). LCMS for C25H27ClN7O2 (M+H)+: m/z=492.2.

Provenance & Evidence