Ethanesulfonyl chloride → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[1-(ethylsulfonyl)piperidin-4-yl]acetamide bis(trifluoroacetate)

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A42, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and ethanesulfonyl chloride as starting materials in 45% yield. 1H NMR (300 MHz, DMSO-d6): δ 10.00 (s, 1H), 9.40 (m, 2H), 8.98 (s, 1H), 8.28 (m, 2H), 8.21 (s, 1H), 7.65 (m, 1H), 7.30 (m, 1H), 7.07 (m, 1H), 3.60 (m, 2H), 2.99 (m, 6H), 2.81 (m, 2H), 2.32 (m, 2H), 1.91 (m, 1H), 1.80 (m, 2H), 1.25 (m, 2H), 1.20 (t, 3H). LCMS for C26H31ClN7O3S (M+H)+: m/z=556.2.

Provenance & Evidence