Pyrazinecarbonyl chloride → HCID 86636166, compound

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A20, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and pyrazine-2-carbonyl chloride as starting materials in 46% yield. 1H NMR (300 MHz, DMSO-d6): δ 10.10 (s, 1H), 9.40 (m, 2H), 9.05 (s, 1H), 8.80 (s, 1H), 8.71 (s, 1H), 8.67 (s, 1H), 8.32 (d, 2H), 8.20 (s, 1H), 7.65 (s, 1H), 7.30 (d, 1H), 7.04 (d, 1H), 4.52 (d, 1H), 3.62 (d, 1H), 3.12 (m, 1H), 2.98 (m, 4H), 2.88 (m, 1H), 2.34 (m, 2H), 2.12 (m, 1H), 1.82 (m, 1H), 1.70 (m, 1H), 1.25 (m, 2H). LCMS for C29H29ClN9O2 (M+H)+: m/z=570.2.

Provenance & Evidence