1-Methyl-1H-pyrazole-3-carbonyl chloride → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(1-methyl-1H-pyrazol-3-yl)carbonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)

Beteiligte Stoffe

Reaktionsschritte

The desired compound was prepared according to the procedure of Example A20, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and 1-methyl-1H-pyrazole-3-carbonyl chloride as starting materials in 36% yield. 1H NMR (300 MHz, DMSO-d6): δ 10.08 (s, 1H), 9.41 (s, 2H), 9.02 (s, 1H), 8.30 (m, 2H), 8.20 (s, 1H), 7.72 (s, 1H), 7.65 (s, 1H), 7.30 (d, 1H), 7.05 (d, 1H), 6.47 (s, 1H), 4.52 (m, 2H), 3.83 (s, 3H), 3.12 (m, 1H), 2.98 (m, 4H), 2.77 (m, 1H), 2.32 (m, 2H), 2.12 (m, 1H), 1.80 (m, 2H), 1.20 (m, 2H). LCMS for C29H31ClN9O2 (M+H)+: m/z=572.2.

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