3-Isocyanatopyridine → HCID 86636193, compound

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A9, step H using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and 3-isocyanatopyridine as starting materials in 46% yield. 1H NMR (300 MHz, DMSO-d6): δ 10.00 (s, 1H), 9.41 (m, 2H), 9.24 (s, 1H), 8.98 (s, 2H), 8.40 (m, 1H), 8.30 (m, 3H), 8.20 (s, 1H), 7.72 (m, 1H), 7.65 (s, 1H), 7.30 (d, 1H), 7.05 (d, 1H), 4.15 (m, 2H), 2.98 (m, 6H), 2.32 (m, 2H), 2.12 (m, 1H), 1.80 (m, 2H), 1.20 (m, 2H). LCMS for C30H31ClN9O2 (M+H)+: m/z=584.2.

Provenance & Evidence