HuagongsheHuagongshe Chemistry Print Report · For research reference only
[1-(1,3,4-Thiadiazol-2-yl)piperidin-4-yl]acetic acid trifluoroacetate → N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl]acetamide bis(trifluoroacetate)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [1-(1,3,4-Thiadiazol-2-yl)piperidin-4-yl]acetic acid trifluoroacetate | HCID 66881289 | — |
| Reactant | 6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-amine Dihydrochloride | HCID 66896050 | — |
| Product | N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl]acetamide bis(trifluoroacetate) | HCID 86636217 | 27% |
Reaction Steps
The desired compound was prepared according to the procedure of Example A169, step B using 6-chloro2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-amine dihydrochloride and [1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl]acetic acid trifluoroacetate as starting materials in 27% yield. LCMS for C27H28ClN8OS (M+H)+: m/z=547.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871753B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-a7659e5412a4468899533e2431776e55 |
| Source note | uspto-grants-2014_10 |