HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nicotinoyl chloride → HCID 86636218, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nicotinoyl chloride | HCID 82604 | — |
| Reactant | N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) | HCID 86636208 | — |
| Product | HCID 86636218 | HCID 86636218 | 37% |
Reaction Steps
The desired compound was prepared according to the procedure of Example A20 using of N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) and nicotinoyl chloride as starting materials in 37% yield. LCMS for C30H30ClN8O2 (M+H)+: m/z=569.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871753B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-8d26192ff50547df949e8319799f4485 |
| Source note | uspto-grants-2014_10 |