Pyridine-3-sulfonyl chloride hydrochloride → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[1-(pyridin-3-ylsulfonyl)piperidin-4-yl]acetamide tris(trifluoroacetate)

Participants

Role	Name	HCID	Charge
Reactant	Pyridine-3-sulfonyl chloride hydrochloride	HCID 12571517	—
Reactant	N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate)	HCID 86636131	—
Product	N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[1-(pyridin-3-ylsulfonyl)piperidin-4-yl]acetamide tris(trifluoroacetate)	HCID 86636232	31%

Reaction Steps

The desired compound was prepared according to the procedure of Example A42 using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and pyridine-3-sulfonyl chloride hydrochloride as starting materials in 31% yield. LCMS for C29H30ClN8O3S (M+H)+: m/z=605.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08871753B2
Source dataset	uspto-grants-2014_10
ORD ID	ord-813ca38afda547e3b681e4436eabdf49
Source note	uspto-grants-2014_10