5-Cyclopropylisoxazole-4-carboxylic acid → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(5-cyclopropylisoxazol-4-yl)carbonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A27 using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and 5-cyclopropylisoxazole-4-carboxylic acid as starting materials in 18% yield. LCMS for C31H32ClN8O3 (M+H)+: m/z=599.2.

Provenance & Evidence