2-Amino-4-thiazolecarboxylic acid hydrobromide → 2-{1-[(2-Amino-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}-N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]acetamide tris(trifluoroacetate)

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example A27 using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and 2-amino-1,3-thiazole-4-carboxylic acid hydrobromide as starting materials in 36% yield. LCMS for C28H29ClN9O2S (M+H)+: m/z=590.2.

Provenance & Evidence