2,4,5-Trichloropyrimidine → HCID 57962665, compound

HRID 541745Notes

Reaction equation

HRID 541745 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:16][CH2:17][C:18]2[CH:19]=[C:20]([NH:24][C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH:21]=[CH:22][CH:23]=2)[CH:5]=[C:6]([S:8]([NH:11][C:12]([CH3:15])([CH3:14])[CH3:13])(=[O:10])=[O:9])[CH:7]=1.[Cl:32][C:33]1[N:38]=[C:37](Cl)[C:36]([Cl:40])=[CH:35][N:34]=1>>[C:12]([NH:11][S:8]([C:6]1[CH:5]=[C:4]([CH2:16][CH2:17][C:18]2[CH:19]=[C:20]([NH:24][C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH:21]=[CH:22][CH:23]=2)[CH:3]=[C:2]([NH:1][C:35]2[C:36]([Cl:40])=[CH:37][N:38]=[C:33]([Cl:32])[N:34]=2)[CH:7]=1)(=[O:10])=[O:9])([CH3:14])([CH3:15])[CH3:13]

Participants

3

Reactant 2

HCID 2372592,4,5-TrichloropyrimidineHCID 57962385HCID 57962385, compound

Product 1

HCID 57962665HCID 57962665, compoundYield 35%

Procedure

The desired compound was prepared according to the procedure of Example B5, step G using tert-butyl [3-(2-{3-amino-5-[(tert-butylamino)sulfonyl]phenyl}ethyl)phenyl]carbamate and 2,4,5-trichloropyrimidine as the starting materials in 35% yield. LCMS for C27H33Cl2N5O4SNa (M+Na)+: m/z=616.2, 618.2.

Sources & evidence

ORD record
ord-5b6045385a8642ce9d34058cb687cae6
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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