反应详情

To a solution of tert-butyl [5-({5-amino-2-[(tert-butoxycarbonyl)amino]phenyl}ethynyl)pyridin-3-yl]carbamate (1.50 g, 3.53 mmol) in methanol (30 mL) was added 10% palladium on carbon (150 mg, 0.141 mmol), and the mixture was hydrogenated under 25 psi of H2 for 2 hours with shaking. The solution was filtered through a pad of celite, and filtrate was concentrated. The residue was purified by flash column chromatography to give the desired product (1.40 g, 92%). LCMS calculated for C23H33N4O4(M+H)+: m/z=429.1.

1. filtrationThe solution was filtered through a pad of celite, and filtrate
2. concentrationwas concentrated
3. customThe residue was purified by flash column chromatography