HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4,5-Trichloropyrimidine → tert-Butyl [5-(2-{2-[(tert-butoxycarbonyl)amino]-5-[(2,5-dichloropyrimidin-4-yl)amino]phenyl}ethyl)pyridin-3-yl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| Reactant | tert-Butyl [5-(2-{5-amino-2-[(tert-butoxycarbonyl)amino]phenyl}ethyl)pyridin-3-yl]carbamate | HCID 57961667 | — |
| Product | tert-Butyl [5-(2-{2-[(tert-butoxycarbonyl)amino]-5-[(2,5-dichloropyrimidin-4-yl)amino]phenyl}ethyl)pyridin-3-yl]carbamate | HCID 57962746 | 43% |
Reaction Steps
This compound was prepared according to the procedure of Example B19 step E, using tert-butyl [5-(2-{5-amino-2-[(tert-butoxycarbonyl)amino]phenyl}ethyl)pyridin-3-yl]carbamate and 2,4,5-trichloropyrimidine as the starting materials in 43% yield. LCMS calculated for C27H33Cl2N6O4(M+H)+: m/z=575.1, 577.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871753B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-b5b954ce00cb4835b5b8194e33d3f8e4 |
| Source note | uspto-grants-2014_10 |