tert-Butanol → HCID 57962653, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene-11-carboxylic acid (9.2 mg, 25.1 μmol) in tert-butyl alcohol (0.16 mL) was added triethylamine (3.5 μL, 25.1 μmol) and diphenylphosphonic azide (5.4 μL, 25.1 μmol). The resulting mixture was heated at 85° C. overnight. The reaction mixture was diluted with DMSO and purified with preparative LCMS to give the desired product (6 mg, 55%). 1H NMR (400 MHz, DMSO-d6): δ 9.33 (s, 1H), 9.22 (s, 1H), 8.09 (s, 1H), 7.92 (s, 1H), 7.31 (m, 2H), 7.08 (t, 1H), 7.03 (s, 1H), 6.88 (dd, 1H), 6.80 (dd, 1H), 2.80 (d, 4H), 1.46 (s, 9H). LCMS calculated for C23H25ClN5O2(M+H)+: m/z=438.2.

Provenance & Evidence