Pyridine-2-carbonyl chloride → N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-11-yl]pyridine-2-carboxamide Trifluoroacetate

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example B26, using 6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-11-amine bis(trifluoroacetate) and pyridine-2-carbonyl chloride as the starting materials in 35% yield. LCMS for C24H20ClN6O (M+H)+: m/z=443.2. 1H NMR (400 MHz, DMSO-d6): δ 10.54 (s, 1H), 9.51 (s, 2H), 8.72 (m, 1H), 8.16 (s, 1H), 8.13 (m, 1H), 8.05 (m, 1H), 7.92 (m, 1H), 7.75 (m, 1H), 7.66 (m, 1H), 7.49 (m, 1H), 7.45 (m, 1H), 7.11 (dd, 1H), 6.89 (m, 1H), 6.84 (m, 1H), 2.89 (m, 4H).

Provenance & Evidence