Phenyl isocyanate → N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-11-yl]-N'-phenylurea Trifluoroacetate

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example B83, using 6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-11-amine bis(trifluoroacetate) and phenyl isocyanate as the starting materials in 28% yield. LCMS for C25H22ClN6O (M+H)+: m/z=457.2. 1H NMR (400 MHz, DMSO-d6): δ 9.39 (s, 1H), 9.28 (s, 1H), 8.69 (s, 1H), 8.64 (s, 1H), 8.08 (s, 1H), 7.90 (m, 1H), 7.40 (m, 2H), 7.31 (m, 1H), 7.22 (m, 3H), 7.06 (dd, 1H), 7.01 (m, 1H), 6.89 (m, 2H), 6.78 (m, 1H), 2.80 (m, 4H).

Provenance & Evidence