1-Methyl-1H-pyrazole-3-carbonyl chloride → N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-11-yl]-1-methyl-1H-pyrazole-3-carboxamide Trifluoroacetate

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example B26, using 6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-11-amine bis(trifluoroacetate) and 1-methyl-1H-pyrazole-3-carbonyl chloride as the starting materials in 47% yield. LCMS for C23H21ClN7O (M+H)+: m/z=446.2. 1H NMR (400 MHz, DMSO-d6): δ 9.93 (s, 1H), 9.76 (s, 1H), 9.70 (s, 1H), 8.20 (s, 1H), 7.88 (m, 1H), 7.82 (d, 1H), 7.64 (m, 1H), 7.42 (m, 1H), 7.36 (m, 1H), 7.11 (dd, 1H), 6.87 (m, 2H), 6.73 (d, 1H), 3.94 (s, 3H), 2.86 (m, 4H).

Provenance & Evidence