1,3-Thiazole-2-carbonyl chloride → N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-11-yl]-1,3-thiazole-2-carboxamide Trifluoroacetate

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Reaction Steps

The desired compound was prepared according to the procedure of Example B26, using 6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-11-amine bis(trifluoroacetate) and 1,3-thiazole-2-carbonyl chloride as the starting materials in 37% yield. LCMS for C22H18ClN6OS (M+H)+: m/z=449.2. 1H NMR (400 MHz, DMSO-d6): δ 10.67 (s, 1H), 9.57 (m, 2H), 8.13 (s, 1H), 8.07 (m, 2H), 7.84 (m, 1H), 7.60 (m, 1H), 7.45 (m, 1H), 7.40 (m, 1H), 7.07 (dd, 1H), 6.85 (m, 2H), 2.84 (m, 4H).

Provenance & Evidence