2,4,5-Trichloropyrimidine → HCID 86636263, compound

HRID 541795Notes

Reaction equation

HRID 541795 reaction equation
[NH2:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[C:4]([I:18])[CH:3]=1.[Cl:19][C:20]1[N:25]=[C:24](Cl)[C:23]([Cl:27])=[CH:22][N:21]=1>>[Cl:19][C:20]1[N:25]=[C:24]([NH:1][C:2]2[CH:17]=[CH:16][C:5]([CH2:6][CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[C:4]([I:18])[CH:3]=2)[C:23]([Cl:27])=[CH:22][N:21]=1

Participants

3

Reactant 2

HCID 2372592,4,5-TrichloropyrimidineHCID 86636261HCID 86636261, compound

Product 1

HCID 86636263HCID 86636263, compoundYield 57%

Procedure

The desired compound was prepared according to the procedure of Example B5, step G using tert-butyl (4-amino-2-iodobenzyl)methylcarbamate and 2,4,5-trichloropyrimidine as the starting materials in 57% yield. LCMS for C17H20Cl21N4O2 (M+H)+: m/z=509.1, 511.1.

Sources & evidence

ORD record
ord-2cb00145230a43eb8aa3060bde347c10
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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