Hydrochloric Acid → N-(3-Aminobenzyl)-3-nitrobenzenesulfonamide Hydrochloride

Participants

Reaction Steps

tert-Butyl [3-({[(3-nitrophenyl)sulfonyl]amino}methyl)phenyl]carbamate (1.00 g, 2.45 mmol) was mixed with 4 M of hydrogen chloride in 1,4-dioxane (10 mL) and stirred at rt for 2 h. After concentration, the crude off-white powder product (0.97 g) was used in the next step. (Molecular Formula (MF)=C13H13N3O4S; LCMS calculated for C13H13N3O4S (M+H)+: m/z=308.0. 1H NMR (400 MHz, CD3OD): δ 8.55 (t, J=2.0 Hz, 1H), 8.44 (ddd, J=8.4, 2.4, 1.2 Hz, 1H), 8.20 (ddd, J=7.6, 2.4, 1.2 Hz, 1H), 7.81 (t, J=8.0 Hz, 1H), 7.40 (m, 2H), 7.36 (dd, J=7.6, 1.2 Hz, 1H), 7.23 (ddd, J=8.0, 2.4, 1.2, 1H), 4.21 (s, 2H).

Provenance & Evidence