Hydrochloric Acid → N-{3-[2-(4-Aminopyridin-2-yl)ethyl]phenyl}-2,5-dichloropyrimidin-4-amine Dihydrochloride

Participants

Reaction Steps

To a mixture of tert-butyl [2-(2-{3-[(2,5-dichloropyrimidin-4-yl)amino]phenyl}ethyl)pyridin-4-yl]carbamate (0.75 g, 1.6 mmol) in 1,4-dioxane (3.0 mL) was added 4 M hydrogen chloride in 1,4-dioxane (7.1 mL). The resultant reaction mixture was stirred at rt for 2 hours. The reaction mixture was concentrated under vacuum to give the desired product as a light yellow powder (0.67 g, 95%). LCMS for C17H16Cl2N5 (M+H)+: m/z=360.2, 362.0.

Provenance & Evidence