HCID 57961596, compound → tert-Butyl {2-[2-(3-aminophenyl)ethyl]pyridin-4-yl}carbamate

Participants

Reaction Steps

To a mixture of tert-butyl {2-[(3-aminophenyl)ethynyl]pyridin-4-yl}carbamate (250 mg, 1.62 mmol) (prepared in Example C12, step A) in methanol (10 mL) was added 10% palladium on carbon (0.30 g, 0.24 mmol). The reaction mixture was hydrogenated at 50 psi overnight. The resultant mixture was filtered and concentrated to provide the desired product (240 mg, 95%) as a white solid. LCMS for C18H24N3O2 (M+H)+: m/z=314.0.

Provenance & Evidence